Rats can be infected with rodent hepacivirus (RHV), a close relative of human hepatitis C virus (HCV). RHV causes a similar pathology to HCV in rats with progressive liver damage, infiltration of activated T cells into the liver with 70 per cent of animals developing a live- long chronic infection.
As rats can be infected with RHV they can be used to study the correlates of protection and how immunity develops to hepaciviruses.
Outcomes
- Poster at International Symposium on HCV and related viruses, Seoul South Korea 2019
Partners +
Collaborators
- Professor Ellie Barnes, Oxford University, UK
- Professor Paul Klenerman, Oxford University, UK
- Professor Peter Simmonds, Oxford University, UK
Project
Team
Meet the project team. Together, we are translating research into better health, for all.
