Traditionally, most studies of immunity only measure antibody levels at a single time point, and fail to capture the dynamic nature of these responses and changes over time that may alter people’s susceptibility to infection and disease.
This study will measure antibody responses to a range of malaria antigens at regular time points in children living in malaria-endemic countries.
Statistical analysis and modelling approaches will be used to examine the relationship between these responses and subsequent protection from symptomatic malaria in these children.
These findings will be especially important in identifying threshold antibody concentrations that are required for protection against malaria, and in developing new serological surveillance tools to determine the prevalence of malaria infection within study populations.
