Monoclonal Antibodies Directed toward the Hepatitis C Virus Glycoprotein E2 Detect Antigenic Differences Modulated by the N-Terminal Hypervariable Region 1 (HVR1), HVR2, and Intergenotypic Variable Region.
Alhammad Y, Gu J, Boo I, Harrison D, McCaffrey K, Vietheer PT, Edwards S, Quinn C, Coulibaly F, Poumbourios P, Drummer HE
Distinct roles in folding, CD81 receptor binding and viral entry for conserved histidine residues of hepatitis C virus glycoprotein E1 and E2.
Boo I, teWierik K, Douam F, Lavillette D, Poumbourios P, Drummer HE
Hepatitis C virus (HCV) envelope glycoproteins E1 and E2 contain reduced cysteine residues essential for virus entry.
Fraser J, Boo I, Poumbourios P, Drummer HE
Hepatitis C
The variable regions of hepatitis C virus glycoprotein E2 have an essential structural role in glycoprotein assembly and virion infectivity.
McCaffrey K, Gouklani H, Boo I, Poumbourios P, Drummer HE
Immunizations with chimeric hepatitis B virus-like particles to induce potential anti-hepatitis C virus neutralizing antibodies.
Vietheer PT, Boo I, Drummer HE, Netter HJ
Expression and characterization of a minimal hepatitis C virus glycoprotein E2 core domain that retains CD81 binding.
McCaffrey K, Boo I, Poumbourios P, Drummer HE