close search

The role of CAMKK2 polymorphisms in HIV-associated sensory neuropathy in South Africans.

Gaff J, Pillay P, Cherry C, Laws SM, Price P, Kamerman P

VIEW FULL ARTICLE
  • Journal Journal of the neurological sciences

  • Published 15 Jun 2020

  • Volume 416

  • Pagination 116987

  • DOI 10.1016/j.jns.2020.116987

Abstract

= 0.26). The results support a role for CAMKK2 in HIV-SN, independent of mechanisms invoked by stavudine. SIGNIFICANCE STATEMENT: HIV-associated sensory neuropathy (HIV-SN) remains a clinically relevant complication of HIV infection and its treatment, affecting 38% of patients treated without neurotoxic stavudine. HIV-SN can impact an individual's ability to work and quality of life, with few effective therapeutic options, so an understanding of the underlying mechanisms would have clinical value. We confirm that CAMKK2 polymorphisms and haplotypes influence susceptibility to HIV-SN in South Africans treated without stavudine. This provides further evidence for a role for the protein encoded by CAMKK2 in the pathogenesis of HIV-SN, independent of mechanisms initiated by stavudine.