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Polymorphisms in CAMKK2 associate with susceptibility to sensory neuropathy in HIV patients treated without stavudine.

Gaff J, Octaviana F, Ariyanto I, Cherry C, Laws SM, Price P

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  • Journal Journal of neurovirology

  • Published 15 Jul 2019

  • Volume 25

  • ISSUE 6

  • Pagination 814-824

  • DOI 10.1007/s13365-019-00771-w

Abstract

 = 0.11). CAMKK2 haplogroup A (includes 16 haplotypes and all instances of rs7975295*C, rs1560568*A, rs1132780*T) associated with reduced rates of HIV-SN (p = 0.02, OR = 0.43 CI = 0.21-0.88). These findings support a protective role for these three alleles, suggesting a role in the pathogenesis of HIV-SN that is independent of stavudine.