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No Evidence that Knops Blood Group Polymorphisms Affect Complement Receptor 1 Clustering on Erythrocytes.

Swann OV, Harrison EM, Opi DH, Nyatichi E, Macharia A, Uyoga S, Williams TN, Rowe JA

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  • Journal Scientific reports

  • Published 19 Dec 2017

  • Volume 7

  • ISSUE 1

  • Pagination 17825

  • DOI 10.1038/s41598-017-17664-9

Abstract

individuals. However, this association was lost when the strong effect of CR1 copy number was included in the model. No association was observed between Sl genotype, sickle cell genotype, α+thalassaemia genotype, gender or age and CR1 cluster number or volume. Therefore, after correction for CR1 copy number, the Sl and McCoy polymorphisms did not influence erythrocyte CR1 clustering, and the effects of the Knops polymorphisms on CR1 function remains unknown.