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Fc engineered ACE2-Fc is a potent multifunctional agent targeting SARS-CoV2.

Wines BD, Kurtovic L, Trist HM, Esparon S, Lopez E, Chappin K, Chan LJ, Mordant FL, Lee WS, Gherardin NA, Patel SK, Hartley GE, Pymm P, Cooney JP, Beeson JG, Godfrey DI, Burrell LM, van Zelm MC, Wheatley AK, Chung AW, Tham WH, Subbarao K, Kent SJ, Hogarth PM

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  • Journal Frontiers in Immunology

  • Published 28 Jul 2022

  • Volume 13

  • Pagination 889372

  • DOI 10.3389/fimmu.2022.889372

Abstract

FcγRIIIa. These different immune profiles demonstrate the capacity of Fc-based agents to be engineered to optimize different mechanisms of protection for SARS-CoV-2 and potentially other viral pathogens.