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Differential expression of HIV envelope epitopes on the surface of HIV-Infected macrophages and CD4<sup>+</sup> T cells.

Kek H, Laumaea A, Parise S, Poumbourios P, Hearps AC, Jaworowski A

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  • Journal Antiviral research

  • Published 05 May 2021

  • Volume 191

  • Pagination 105085

  • DOI 10.1016/j.antiviral.2021.105085

Abstract

-infected macrophages were more susceptible to opsonisation by NIH45-46 (median = 40.4%) compared to infected T cells (13.6%; p = 0.002), which were more susceptible to opsonisation by 17b and 447.52D (88.6% and 45.6% respectively) compared to MDM (30% and 6.7%, p = 0.002 and 0.004 respectively). Furthermore, neutralising antibodies 10E8 and PGT145 were relatively ineffective at opsonising Env expressed on the surface of infected T cells or macrophages, indicating that the context in which Env is presented on infected cells may differ to that of cell-free virions.