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Developments in drug design strategies for bromodomain protein inhibitors to target Plasmodium falciparum parasites.

Nguyen HHT, Yeoh LM, Chisholm SA, Duffy MF

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  • Journal Expert opinion on drug discovery

  • Published 23 Dec 2019

  • Volume 15

  • ISSUE 4

  • Pagination 415-425

  • DOI 10.1080/17460441.2020.1704251

Abstract

phenotypic screens. These targeted libraries and hits could be screened in target-based strategies aimed at discovery and optimization of novel inhibitors of PfBDPs. A key task for the field is to generate parasite assays to validate the hit compounds' specificity for PfBDPs.