Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS
VIEW FULL ARTICLEJournal Nature communications
Published 29 Nov 2021
Volume 12
ISSUE 1
Pagination 6963
DOI 10.1038/s41467-021-27161-3
BM-SEC reveal aberrant sinusoidal differentiation with altered EC gene expression and perisinusoidal ECM deposition and angiocrine dysregulation with de novo endothelial expression of FGF23 and DKK2, elevated in anemia and involved in vascular stabilization, respectively. Our study demonstrates that BM-SEC play an important role in the bone marrow microenvironment in health and disease.