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A pan-genotype hepatitis C virus viral vector vaccine generates T cells and neutralizing antibodies in mice.

Donnison T, McGregor J, Chinnakannan S, Hutchings C, Center RJ, Poumbourios P, Klenerman P, Drummer HE, Barnes E

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  • Journal Hepatology (Baltimore, Md.)

  • Published 19 May 2022

  • Volume 76

  • ISSUE 4

  • Pagination 1190-1202

  • DOI 10.1002/hep.32470

Abstract

), generates pan-genotypic T cells and nAbs, respectively. We now aim to develop a vaccine to generate both viral-specific B- and T-cell responses concurrently.

protein, while also generating high-magnitude T-cell responses.

These data are an important step forward for the development of a pan-genotype HCV vaccine to elicit T cells and nAbs for future assessment in humans.